Gene information
Official symbol AKT1
Official full name AKT serine/threonine kinase 1
Gene type protein-coding gene
Chromosome14q32.33
Alias symbolRAC; PKB; PRKBA; AKT; RAC-alpha
Gene familyPleckstrin homology domain containing; AKT kinases
Resources
Entrez Gene 207
HGNC HGNC:391
Ensembl ENSG00000142208
Vega OTTHUMG00000170795
UCSC uc001ypm.4
GO terms: 188 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001649 osteoblast differentiation GO Biological Processes -6.81659337 21 More
GO:0001667 ameboidal-type cell migration GO Biological Processes -17.0771232 40 More
GO:0001701 in utero embryonic development GO Biological Processes -8.76987260 44 More
GO:0001890 placenta development GO Biological Processes -8.66149584 25 More
GO:0001892 embryonic placenta development GO Biological Processes -3.02613520 11 More
GO:0001933 negative regulation of protein phosphorylation GO Biological Processes -19.8214973 59 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001938 positive regulation of endothelial cell proliferation GO Biological Processes -32.0012114 45 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002028 regulation of sodium ion transport GO Biological Processes -2.33647794 5 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002686 negative regulation of leukocyte migration GO Biological Processes -7.70467721 14 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0005543 phospholipid binding GO Molecular Functions -6.61792344 45 More
GO:0005911 cell-cell junction GO Cellular Components -3.41801827 38 More
GO:0005975 carbohydrate metabolic process GO Biological Processes -4.30473825 38 More
GO:0006112 energy reserve metabolic process GO Biological Processes -4.0688237 6 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0006469 negative regulation of protein kinase activity GO Biological Processes -12.6852914 37 More
GO:0006606 protein import into nucleus GO Biological Processes -2.02717768 5 More
GO:0006913 nucleocytoplasmic transport GO Biological Processes -1.63729080 7 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007268 chemical synaptic transmission GO Biological Processes -4.44678751 35 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0008593 regulation of Notch signaling pathway GO Biological Processes -4.89883771 15 More
GO:0009266 response to temperature stimulus GO Biological Processes -12.1149168 32 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009792 embryo development ending in birth or egg hatching GO Biological Processes -12.9988944 72 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010001 glial cell differentiation GO Biological Processes -13.0211768 33 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010038 response to metal ion GO Biological Processes -20.5090881 61 More
GO:0010506 regulation of autophagy GO Biological Processes -5.54010569 34 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010565 regulation of cellular ketone metabolic process GO Biological Processes -15.3155739 32 More
GO:0010594 regulation of endothelial cell migration GO Biological Processes -41.8778170 72 More
GO:0010595 positive regulation of endothelial cell migration GO Biological Processes -28.3201829 45 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0010639 negative regulation of organelle organization GO Biological Processes -2.25995266 25 More
GO:0010763 positive regulation of fibroblast migration GO Biological Processes -3.56180292 5 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0010975 regulation of neuron projection development GO Biological Processes -5.89330331 41 More
GO:0015459 potassium channel regulator activity GO Molecular Functions -2.41427787 4 More
GO:0016241 regulation of macroautophagy GO Biological Processes -3.91265693 18 More
GO:0016247 channel regulator activity GO Molecular Functions -2.78567165 7 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0019901 protein kinase binding GO Molecular Functions -6.66055444 59 More
GO:0021782 glial cell development GO Biological Processes -9.97103962 23 More
GO:0022408 negative regulation of cell-cell adhesion GO Biological Processes -15.9068791 40 More
GO:0030027 lamellipodium GO Cellular Components -1.61995196 15 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0031252 cell leading edge GO Cellular Components -1.97716247 28 More
GO:0031331 positive regulation of cellular catabolic process GO Biological Processes -13.5134767 30 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0032091 negative regulation of protein binding GO Biological Processes -7.69848876 11 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032768 regulation of monooxygenase activity GO Biological Processes -14.2762890 21 More
GO:0032770 positive regulation of monooxygenase activity GO Biological Processes -9.70418585 13 More
GO:0032868 response to insulin GO Biological Processes -11.6850377 35 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0032890 regulation of organic acid transport GO Biological Processes -14.1608908 23 More
GO:0033500 carbohydrate homeostasis GO Biological Processes -23.7918768 50 More
GO:0033555 multicellular organismal response to stress GO Biological Processes -7.79385832 16 More
GO:0033673 negative regulation of kinase activity GO Biological Processes -12.5521161 39 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034405 response to fluid shear stress GO Biological Processes -8.30035543 8 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034763 negative regulation of transmembrane transport GO Biological Processes -22.14661 42 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0036294 cellular response to decreased oxygen levels GO Biological Processes -14.5279047 32 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042063 gliogenesis GO Biological Processes -20.3412228 47 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0042391 regulation of membrane potential GO Biological Processes -15.0641346 59 More
GO:0042593 glucose homeostasis GO Biological Processes -23.8963802 50 More
GO:0042692 muscle cell differentiation GO Biological Processes -15.1559811 45 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043009 chordate embryonic development GO Biological Processes -11.8113315 68 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0043393 regulation of protein binding GO Biological Processes -7.80142307 15 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045428 regulation of nitric oxide biosynthetic process GO Biological Processes -19.2075726 26 More
GO:0045429 positive regulation of nitric oxide biosynthetic process GO Biological Processes -13.6962150 18 More
GO:0045732 positive regulation of protein catabolic process GO Biological Processes -6.83749864 15 More
GO:0045833 negative regulation of lipid metabolic process GO Biological Processes -7.94928400 20 More
GO:0045834 positive regulation of lipid metabolic process GO Biological Processes -24.1838255 28 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048568 embryonic organ development GO Biological Processes -17.1204114 64 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048661 positive regulation of smooth muscle cell proliferation GO Biological Processes -29.0732096 40 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050679 positive regulation of epithelial cell proliferation GO Biological Processes -31.4834672 59 More
GO:0050994 regulation of lipid catabolic process GO Biological Processes -9.86212956 11 More
GO:0050995 negative regulation of lipid catabolic process GO Biological Processes -4.91348267 5 More
GO:0050999 regulation of nitric-oxide synthase activity GO Biological Processes -9.05830591 14 More
GO:0051000 positive regulation of nitric-oxide synthase activity GO Biological Processes -5.74582458 8 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051098 regulation of binding GO Biological Processes -15.8856010 30 More
GO:0051100 negative regulation of binding GO Biological Processes -8.85516089 15 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051146 striated muscle cell differentiation GO Biological Processes -10.9431474 33 More
GO:0051169 nuclear transport GO Biological Processes -1.63729080 7 More
GO:0051170 import into nucleus GO Biological Processes -1.96322846 5 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051341 regulation of oxidoreductase activity GO Biological Processes -18.1249013 32 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051348 negative regulation of transferase activity GO Biological Processes -13.2006110 43 More
GO:0051353 positive regulation of oxidoreductase activity GO Biological Processes -12.6682372 20 More
GO:0055094 response to lipoprotein particle GO Biological Processes -14.9317808 12 More
GO:0060078 regulation of postsynaptic membrane potential GO Biological Processes -2.74505261 11 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0060711 labyrinthine layer development GO Biological Processes -3.15848951 8 More
GO:0061061 muscle structure development GO Biological Processes -23.2569142 77 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0062012 regulation of small molecule metabolic process GO Biological Processes -26.8746473 69 More
GO:0062013 positive regulation of small molecule metabolic process GO Biological Processes -17.9792910 37 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071241 cellular response to inorganic substance GO Biological Processes -4.23170629 23 More
GO:0071248 cellular response to metal ion GO Biological Processes -4.26641514 21 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071375 cellular response to peptide hormone stimulus GO Biological Processes -15.9961580 44 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071402 cellular response to lipoprotein particle stimulus GO Biological Processes -16.0665913 13 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0071453 cellular response to oxygen levels GO Biological Processes -14.8173809 34 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071901 negative regulation of protein serine/threonine kinase activity GO Biological Processes -13.7044922 29 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0080164 regulation of nitric oxide metabolic process GO Biological Processes -19.7892071 27 More
GO:0090130 tissue migration GO Biological Processes -11.7623300 24 More
GO:0097305 response to alcohol GO Biological Processes -17.4096682 46 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098794 postsynapse GO Cellular Components -5.82876983 23 More
GO:0098916 anterograde trans-synaptic signaling GO Biological Processes -4.44678751 35 More
GO:0099106 ion channel regulator activity GO Molecular Functions -2.87451539 7 More
GO:0099536 synaptic signaling GO Biological Processes -6.00976162 42 More
GO:0099537 trans-synaptic signaling GO Biological Processes -5.17038357 38 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:1901215 negative regulation of neuron death GO Biological Processes -19.0527525 45 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901653 cellular response to peptide GO Biological Processes -21.5212108 58 More
GO:1901654 response to ketone GO Biological Processes -10.4509771 32 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1904407 positive regulation of nitric oxide metabolic process GO Biological Processes -14.4967625 19 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905953 negative regulation of lipid localization GO Biological Processes -25.1573575 31 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000401 regulation of lymphocyte migration GO Biological Processes -4.96687132 7 More
KEGG pathways: 13 records
KEGG Description Category LogP Number of genes Detail
hsa04022 cGMP-PKG signaling pathway KEGG Pathway -9.74555098 16 More
hsa04024 cAMP signaling pathway KEGG Pathway -7.78464854 30 More
hsa04072 Phospholipase D signaling pathway KEGG Pathway -3.77257282 17 More
hsa04261 Adrenergic signaling in cardiomyocytes KEGG Pathway -3.35554526 8 More
hsa04380 Osteoclast differentiation KEGG Pathway -7.05199617 21 More
hsa04613 Neutrophil extracellular trap formation KEGG Pathway -12.8071279 20 More
hsa04923 Regulation of lipolysis in adipocytes KEGG Pathway -8.97402692 10 More
hsa04931 Insulin resistance KEGG Pathway -8.40376708 21 More
hsa05010 Alzheimer disease KEGG Pathway -5.39034067 17 More
hsa05165 Human papillomavirus infection KEGG Pathway -8.63301470 40 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05207 Chemical carcinogenesis - receptor activation KEGG Pathway -7.05448873 28 More
hsa05224 Breast cancer KEGG Pathway -6.01672252 21 More
Drug-Gene interaction
view
Related drugs: 72 records
Drug name Interaction type Source PMID View
5-methoxycanthinone DTC view
a-443654 inhibitor DTC 19465931 view
afuresertib inhibitor ChemblInteractionsTTD view
alpelisib JAX-CKB 27604488 view
andrographolide DTC 22026410 view
apitolisib JAX-CKB view
archexin TdgClinicalTrialJAX-CKBTTD view
azd-5363 inhibitor ChemblInteractions view
bardoxolone methyl DTC 25675144 view
bay-1125976 inhibitor ChemblInteractions view
bms-754807 TTD view
canertinib TTD view
canthin-6-one DTC view
capivasertib inhibitor MyCancerGenomeClearityFoundationClinicalTrialJAX-CKBCIViCTTDOncoKB 26351323269313432837621228489509 view
carboplatin PharmGKB 22901187 view
cenisertib inhibitor TALCMyCancerGenome view
cep-11981 DTC 22148921 view
cetuximab JAX-CKB 25714871 view
chembl1086397 DTC 20855208 view
chembl225519 DTC view
chembl257158 DTC 20822912 view
chembl258844 DTC 17603540 view
chembl480356 DTC 19110422 view
ci-1040 TTD view
cisplatin JAX-CKBPharmGKB 2290118725519148 view
cmx-2043 TTD view
cyc-116 DTC view
dabrafenib CIViC 24265155 view
doxorubicin JAX-CKB 18708578 view
enzastaurin TTD view
eupalinin a DTC 17980607 view
everolimus inhibitor JAX-CKBMyCancerGenomeClinicalTrial view
fasudil DTC view
gambogic amide DTC 17911251 view
gedatolisib DTC 20166697 view
gemcitabine JAX-CKB view
gigantol DTC 24844664 view
gsk-269962a DTC view
gsk-690693 inhibitor ChemblInteractions view
ipatasertib inhibitor DTCMyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrialJAX-CKBChemblInteractionsMyCancerGenomeClinicalTrialTTD 2293457527872130 view
irinotecan JAX-CKB 25714871 view
lauroguadine DTC view
lovastatin DTC 17472962 view
ly-2780301 inhibitor ChemblInteractions view
ly-294002 DTC 16767085 view
miransertib inhibitorallosteric modulator ChemblInteractions view
mk-2201 inhibitor ChemblInteractions view
mk-2206 inhibitory allosteric modulatorallosteric modulatorinhibitor TALCClearityFoundationBiomarkersMyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrialJAX-CKBChemblInteractionsCancerCommonsMyCancerGenomeClinicalTrial 2426515225551293 view
msc-2363318a inhibitor ChemblInteractionsTTD view
nelfinavir inhibitor TALC view
nintedanib DTC 18559524 view
omipalisib inhibitor MyCancerGenomeClinicalTrial view
onc-201 JAX-CKB 23390247 view
paclitaxel JAX-CKB view
perifosine inhibitor TALCTdgClinicalTrialJAX-CKBMyCancerGenomeClinicalTrial 1820176425519148 view
pictilisib JAX-CKB 27604488 view
resveratrol inhibitor DTC 1751386724968355 view
risperidone PharmGKB 18855532 view
sirolimus JAX-CKB 18708578 view
sorafenib JAX-CKB view
sotrastaurin DTC view
sr-13668 inhibitor ChemblInteractions view
temsirolimus JAX-CKB 27016228 view
topotecan DTC 21440338 view
triciribine ClearityFoundationBiomarkersTdgClinicalTrialClearityFoundationClinicalTrialJAX-CKB 20644979 view
triciribine phosphate inhibitor ChemblInteractions view
trifluoperazine DTC 26372073 view
uprosertib inhibitor JAX-CKBChemblInteractions 24735930249785972379591926429956 view
vemurafenib JAX-CKBCIViC 24265152 view
withaferin a DTC 20726569 view
wortmannin NCI 10187855 view
xl-418 inhibitor TdgClinicalTrialChemblInteractions view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NM_005163.2:c.175+18C>T genomics myocardial infarction[diagnosis] myocardial infarction Leander K et al. Clin Chim Acta. 2012
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